Examples of Structural Motifs in Viral Genomes and Approaches for RNA Structure CharacterizationReview Published on 2022-12-142023-07-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), [키워드] cryo-EM high-throughput methods secondary and tertiary structures structure prediction Viral RNA viruses. [DOI] 10.3390/ijms232415917 PMC 바로가기 [Article Type] Review
Structure-based neutralizing mechanisms for SARS-CoV-2 antibodiesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, [키워드] antibody Antibody structure caused consequence COVID-19 pandemic Critical cryo-EM develop effective effort epitope Host Infection mAbs mechanism molecular monoclonal antibody Neutralizing neutralizing antibody neutralizing mechanism pan-coronavirus vaccine. provide public health SARS-CoV-2 SARS-CoV-2 antibody Scientific community the spike protein Vaccine Vaccines [DOI] 10.1080/22221751.2022.2125348 PMC 바로가기
A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitorsArticle Published on 2022-11-102023-07-10 Journal: Cell [Category] COVID19(2023년), [키워드] capping cryo-EM nucleotide analog inhibitor. SARS-CoV-2 [DOI] 10.1016/j.cell.2022.09.037 PMC 바로가기
Structure of SARS-CoV-2 M protein in lipid nanodiscsArticle Published on 2022-10-202023-07-10 Journal: eLife [Category] COVID19(2023년), [키워드] coronavirus cryo-EM Human molecular biophysics SARS-CoV-2 Structural Biology. [DOI] 10.7554/eLife.81702 PMC 바로가기
DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2Article Published on 2022-10-062022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] administration animal challenge model antibodies antibody cocktail Antigen antiviral potency binding cryo-EM demonstrated Efficacy effort exhibit forms functional High-resolution in vivo Interaction lineages mAb monoclonal antibody monoclonal antibody therapy omicron performed populations promote Prophylactic Prophylaxis Protective Protein SARS-CoV-2 serum antibody specificity Strategy Support trimeric [DOI] 10.1038/s41467-022-33309-6 PMC 바로가기
SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitopeArticle Published on 2022-10-012022-11-15 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Analysis antibodies antibody Antibody binding Antibody Response association competing cryo-EM Delta delta variant disrupt elicit epitope evade host immune responses hydrophobic immune evasion immune response impair inhibiting Interaction L452R Lineage mechanism Mutation neutralization omicron Population SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant spike receptor-binding domain spike variants Spread Substitution substitutions target thought variant virus entry virus variants [DOI] 10.1038/s41564-022-01235-4 PMC 바로가기
Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadthArticle Published on 2022-09-222022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] activity antibodies antibody antibody cocktail antibody resistance binding breadth computational simulation costly COVID-19 crosslinking cryo-EM Engineering epitope exhibit IMPROVE Infection mouse model Neutralizing Neutralizing activity parental RBD reduce SARS-CoV-2 SARS-CoV-2 variant the receptor-binding domain therapeutic efficacy therapy variants virus-neutralizing X-ray crystallography [DOI] 10.1038/s41467-022-33284-y PMC 바로가기
Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding AffinityArticle Published on 2022-09-202022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 치료법, 치료제, [키워드] acute respiratory syndrome adopted affinity analysis anti-SARS-CoV-2 anti-viral activity approved binding affinity binding free energy ChEMBL Chemistry clinical development Compound coronavirus coronavirus disease COVID-19 Cryo-electron microscopy cryo-EM cryo-EM structure database docking drug drug candidates drug library drug repositioning drugs dsRNA fragment molecular orbital calculation Frequency frequency analysis interactions mode molecular Novel coronavirus ONIOM geometry optimization calculation pathogenic PDB performed predicted quantum quantum chemistry calculation RdRP reported reproduction RNA RNA-dependent RNA polymerase SARS-CoV-2 Screening screenings significantly suggested Treatment Virtual screening virtual screening. was performed [DOI] 10.3390/ijms231911009 PMC 바로가기
Molecular Basis of Mink ACE2 Binding to SARS-CoV-2 and Its Mink-Derived VariantsArticle Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acute respiratory syndrome addition angiotensin-converting enzyme 2 Basis binding binding affinity binding mechanism changes in complexes coronavirus Cross-species transmission cryo-EM cryo-EM structure demonstrated examined expressing F486L facilitate highlight hosts Human human cell human monoclonal antibodies humans identify indicated Infection information Interaction mechanism Microscopy mink molecular mechanism Mutation N501T neutralized prevented Protein pseudovirus RBD RBD variant RBD variants receptor reduced residue SARS-CoV-2 SARS-CoV-2 variant sera Structure the binding affinity the RBD the receptor-binding domain the SARS-CoV-2 transmitted variant variants virus entry Virus entry. viruses Y453F [DOI] 10.1128/jvi.00814-22 PMC 바로가기
Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike TrimerSARS-CoV-2 항체의 구조 연구는 스파이크 삼량체를 분해하여 오미크론 변이체를 중화하는 광범위한 항체를 식별합니다Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] accommodation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition aggregation antibody caused conservation conserved convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cryo Cryo-electron microscopy cryo-EM develop Effectiveness electron microscopy epitope Epitopes function hidden IgG Immune escape investigated monoclonal antibodies monoclonal antibody NAb NAbs neutralize Neutralizing antibodies neutralizing antibody neutralizing antibody. omicron Omicron variant pandemic Protein pseudovirus raised raising RBD reagent Receptor binding Receptor binding domain respiratory S trimer S trimers SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants steric hindrance subset target the SARS-CoV-2 the Spike therapeutic therapy trimer Vaccines variant variants of SARS-CoV-2 virion virus VoC VOCs [DOI] 10.1128/jvi.00480-22 PMC 바로가기 [Article Type] Article